Selenium nanoparticles attenuate bleomycin-induced pulmonary oxidative stress and fibrosis in rats

Azza M A. Abouelella, Department of Clinical Pharmacology, Faculty of Medicine, Sohag University PO82524, EgyptFollow
Bahig A. El Deeb, Department of Botany and microbiology, Faculty of science, Sohag University, PO82524. Egypt
Eman Mohammed Ali, Department of Clinical Pharmacology, Faculty of Medicine, Sohag University PO82524, Egypt.

Subject Area

Pharmacology and Clinical Pharmacy

Abstract

Pulmonary fibrosis is a fatal progressive lung disorder. Bleomycin (BLM) has been used for induction of experimental pulmonary fibrosis. Selenium nanoparticles (SeNPs) have been synthesized and investigated for their ability to ameliorate BLM-induced pulmonary fibrosis. SeNPs (0.5 mg⁄kg. ip) were administered for four weeks; two weeks pre and two weeks post BLM (2.5 U⁄kg. ip). BLM induced biochemical and histological deterioration of lungs. SeNPs induced significant histopathological and biochemical improvement of oxidative stress (MDA, SOD and GSH), inflammatory (IL6 and IL10) and fibrotic markers (hydroxyproline). In conclusion; SeNPs has potential therapeutic rather than protective effect on management of pulmonary damage.

Recommended Citation

Abouelella, Azza M A.; Deeb, Bahig A. El; and Ali, Eman Mohammed (2022) "Selenium nanoparticles attenuate bleomycin-induced pulmonary oxidative stress and fibrosis in rats," Bulletin of Faculty of Pharmacy Cairo University: Vol. 60 : Iss. 2 , Article 2.
Available at: https://doi.org/10.54634/2090-9101.1033