Subject Area

Pharmacology and Clinical Pharmacy


All tissues are subjected to the risk of tissue damage. Tissue damage refers to any alteration to the structure and/or the function of that tissue. To counter tissue damage, our bodies are equipped with a self-healing mechanism aiming at restoring tissue structure and function. The underlying mechanism, however, is rather poor and slow in mammalians. Moreover, in cases of severe damage, the mechanism is insufficient to repair the damage and usually, surgical intervention is mandated. For that and more, tissue engineering was conceptualized as a multidisciplinary science field in which an implantable scaffold, loaded with cells, biological cues and/or chemical agents, is utilized to stimulate tissue regeneration. Rosuvastatin calcium is a hydrophilic statin with positive effect on tissue regeneration and wound healing, besides its marketed use as cholesterol-lowering agent. Although there are several routes to drug delivery of statins (such as IV, nasal delivery, implantable delivery, … etc.), the oral route remains the most popular choice. However, owing to the poor oral bioavailability of rosuvastatin, implantable drug delivery is the go-to choice in tissue engineering. Hydrogel scaffolds are particularly favorable in tissue engineering owing to their biocompatibility, hydrophilic nature and high swelling capabilities. The whole system is effective in both soft (tendons) and hard (bones) tissue regeneration. This review sheds light on the implementation of tissue engineering as a favorable approach to wound healing with emphasis on the role of rosuvastatin in tissue regeneration.