Ultradeformable nanocarriers for efficient transdermal drug delivery

Hala N. ElShagea, Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Cairo, Egypt
Rana R. Makar, Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Cairo, Egypt
Alaa H. Salama, Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Cairo, Egypt
Nermeen A. Elkasabgy, Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt.Follow
Emad B. Basalious, Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt.

Subject Area

Pharmaceutical Technology

Abstract

Ultradeformable nanovesicles (UDVs) have recently become one of the favorable tools used for the transdermal delivery of drugs into deep skin layers, leading to enhanced bioavailability and therapeutic effect. UDV are capable of carrying hydrophilic, lipophilic or amphiphilic drugs bypassing the skin barriers. This mini review presents examples of UDV, their advantages, different mechanisms for UDV skin penetration, and some of the recent studies that proved the liability of using such carriers for better skin penetration. The applicability of using UDV for transdermal drug delivery has expanded such that marketed drug products were recently approved and launched indicating its superiority over the conventional dosage forms.

Recommended Citation

ElShagea, Hala N.; Makar, Rana R.; Salama, Alaa H.; Elkasabgy, Nermeen A.; and Basalious, Emad B. (2023) "Ultradeformable nanocarriers for efficient transdermal drug delivery," Bulletin of Faculty of Pharmacy Cairo University: Vol. 61 : Iss. 1 , Article 9.
Available at: https://doi.org/10.54634/2090-9101.1045