Subject Area

Pharmaceutical Technology


Ultradeformable nanovesicles (UDVs) have recently become one of the favorable tools used for the transdermal delivery of drugs into deep skin layers, leading to enhanced bioavailability and therapeutic effect. UDV are capable of carrying hydrophilic, lipophilic or amphiphilic drugs bypassing the skin barriers. This mini review presents examples of UDV, their advantages, different mechanisms for UDV skin penetration, and some of the recent studies that proved the liability of using such carriers for better skin penetration. The applicability of using UDV for transdermal drug delivery has expanded such that marketed drug products were recently approved and launched indicating its superiority over the conventional dosage forms.