Smart Spectrophotometric Approaches for Estimation of Difluprednate in Existence of Its Synthetic Precursor and Alkaline Degradation Product; Comparative Statistical Studies and Analytical Ecological Appraisal

Authors

Heidi R. Abd El-Hadi, Faculty of Pharmacy, Pharmaceutical Chemistry Department, Egyptian Russian University, Badr City, Cairo, Egypt
Basma M. Eltanany, Faculty of Pharmacy, Analytical Chemistry Department, Cairo University, Kasr El-Aini Street, 11562 Cairo, EgyptFollow
Hala E. Zaazaa, Faculty of Pharmacy, Analytical Chemistry Department, Cairo University, Kasr El-Aini Street, 11562 Cairo, Egypt
Maya S. Eissa, Faculty of Pharmacy, Pharmaceutical Chemistry Department, Egyptian Russian University, Badr City, Cairo, Egypt

Corresponding Author

Basma M. Eltanany

Subject Area

General Chemistry

Abstract

Scientists are currently attempting to lessen the harmful effects that chemicals and solvents have on the environment. The current work suggests four sensitive and sustainable spectrophotometric techniques for quantifying difluprednate (DIF) in presence of hydrocortisone acetate, which is a synthetic precursor of DIF, and in the presence of DIF alkaline degradation product. These methods are dual wavelength, fourier self-deconvolution, first derivative, and double divisor derivative ratio. The linearity range for all methods was 15.00-40.00 µg/mL. There is no statistically significant difference between established and reported methods, and the suggested strategies are more environmentally friendly than the reported one.

Recommended Citation

El-Hadi, Heidi R. Abd; Eltanany, Basma M.; Zaazaa, Hala E.; and Eissa, Maya S. (2024) "Smart Spectrophotometric Approaches for Estimation of Difluprednate in Existence of Its Synthetic Precursor and Alkaline Degradation Product; Comparative Statistical Studies and Analytical Ecological Appraisal," Bulletin of Faculty of Pharmacy Cairo University: Vol. 62 : Iss. 1 , Article 4.
Available at: https://doi.org/10.54634/2090-9101.1052

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