Effect of 90-day oral administration of ginger extract on hormonal, haematological and biochemical parameters of Wistar rats: A toxicity study

Musa I. Yakubu, Department of Pharmacology and Toxicology, Kaduna State University, Kaduna, NigeriaFollow
Abdulfatai A. Jimoh, Department of Pharmacology and Toxicology, Kaduna State University, Kaduna, Nigeria
Iliyasu K. Uwais, Department of Pharmacognosy and Drug development, Kaduna State University, Kaduna, Nigeria
Ahmed A. Danbala, Department of Pharmacology and Toxicology, Kaduna State University, Kaduna, Nigeria
Micah Timothy, Department of Pharmacology and Toxicology, Kaduna State University, Kaduna, Nigeria
Medinat Y. Abbas, Department of Pharmacology and Therapeutics, Ahmadu Bello University, Zaria, Nigeria
Ben A. Chindo, Department of Pharmacology and Toxicology, Kaduna State University, Kaduna, Nigeria

Subject Area

Pharmacology and Clinical Pharmacy

Abstract

The study aimed to investigate the effects of long-term consumption of high doses of ginger extract on various parameters in Wistar rats. The study followed OECD 408 testing guidelines and administered oral aqueous ginger extract at doses of 500, 1,000, and 2,000 mg/kg body weight to the rats for 90 days. The rats were euthanized on the 91st day, blood samples collected for biochemical analysis. The ginger extract did not significantly affect haematological, endocrine and oxidative stress parameters. In conclusion, the extract did not result in haematological or endocrine toxicity in rats but positively reduced body weight and cholesterol levels.

Recommended Citation

Yakubu, Musa I.; Jimoh, Abdulfatai A.; Uwais, Iliyasu K.; Danbala, Ahmed A.; Timothy, Micah; Abbas, Medinat Y.; and Chindo, Ben A. (2024) "Effect of 90-day oral administration of ginger extract on hormonal, haematological and biochemical parameters of Wistar rats: A toxicity study," Bulletin of Faculty of Pharmacy Cairo University: Vol. 62 : Iss. 1 , Article 6.
Available at: https://doi.org/10.54634/2090-9101.1060